Advancing Organoid Technologies for Liver Tissue Engineering and Disease Modelling
听We develop and utilise liver organoids鈥攖hree-dimensional models of human liver tissue grown in the lab鈥攖o mimic organ development, disease processes, and therapeutic responses in a controlled environment. Our research focuses on using these 3D multicellular constructs, derived from stem cells or primary cells, to investigate liver physiology, pathology, and regeneration, with a particular emphasis on conditions such as fibrosis and fatty liver disease. By studying fatty liver disease, we aim to better understand its links to metabolic disorders and associated cardiovascular diseases. By integrating advanced quantitative proteomics, we uncover molecular pathways involved in liver diseases, optimise extracellular matrix and cellular niche conditions, and enhance the translational potential of organoids for therapeutic discovery.
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